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KMID : 0378119790060020323
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Chungnam Medical Journal
1979 Volume.6 No. 2 p.323 ~ p.330
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An Experimental Investigation of Articular Cartilage Degeneration induced by Compression-immobilization of Knee Joint in Rabbits
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Abstract
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Articular cartilage have dual functions of shock absorber and bearing surface in a moving joint. Articular cartilage is avascular, so the chondrocytes in mature adult must receive their nourishment solely from synovial-fluid perfusion, and it is known that
alteration of synovial-fluid perfusion causes degeneration of articular cartilage.
Now, in orthopedic fields, the cast immobilization is in popular use, and to study the cartilage changes induced by this long term cast immobilization, the rabbit knee joints were immobilized in a compressed position and serial histologic examination of articular
cartilage up to 5 weeks was done.
The results obtained were as followings;
1. The degenerative changes of articular cartilage were observed at 3 weeks after compression-immobilization.
2. The severity of the histologic changes appeared to be related to the duration of the compression-immobilization.
3. The calcific cartilage zone remained histologically unchanged despite advanced changes in the noncalcified zone superficial to the tidemark.
4. Subchondral bone showed mild hypertrophy at 3 weeks after compression-immobiliz￢ation and degree of hypertrophy was increased with the duration of compression-immobi￢lization.
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